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- Title
FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster.
- Authors
Adryan, Boris; Teichmann, Sarah A
- Abstract
We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 12, p1532
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btl143