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- Title
Improved scoring of functional groups from gene expression data by decorrelating GO graph structure.
- Authors
Alexa, Adrian; Rahnenführer, Jörg; Lengauer, Thomas
- Abstract
The result of a typical microarray experiment is a long list of genes with corresponding expression measurements. This list is only the starting point for a meaningful biological interpretation. Modern methods identify relevant biological processes or functions from gene expression data by scoring the statistical significance of predefined functional gene groups, e.g. based on Gene Ontology (GO). We develop methods that increase the explanatory power of this approach by integrating knowledge about relationships between the GO terms into the calculation of the statistical significance.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 13, p1600
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btl140