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- Title
OrthologID: automation of genome-scale ortholog identification within a parsimony framework.
- Authors
Chiu, Joanna C; Lee, Ernest K; Egan, Mary G; Sarkar, Indra Neil; Coruzzi, Gloria M; DeSalle, Rob
- Abstract
The determination of gene orthology is a prerequisite for mining and utilizing the rapidly increasing amount of sequence data for genome-scale phylogenetics and comparative genomic studies. Until now, most researchers use pairwise distance comparisons algorithms, such as BLAST, COG, RBH, RSD and INPARANOID, to determine gene orthology. In contrast, orthology determination within a character-based phylogenetic framework has not been utilized on a genomic scale owing to the lack of efficiency and automation.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 6, p699
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btk040