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- Title
Sequence-based heuristics for faster annotation of non-coding RNA families.
- Authors
Weinberg, Zasha; Ruzzo, Walter L
- Abstract
Non-coding RNAs (ncRNAs) are functional RNA molecules that do not code for proteins. Covariance Models (CMs) are a useful statistical tool to find new members of an ncRNA gene family in a large genome database, using both sequence and, importantly, RNA secondary structure information. Unfortunately, CM searches are extremely slow. Previously, we created rigorous filters, which provably sacrifice none of a CM's accuracy, while making searches significantly faster for virtually all ncRNA families. However, these rigorous filters make searches slower than heuristics could be.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 1, p35
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti743