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- Title
Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues.
- Authors
Wachi, Shinichiro; Yoneda, Ken; Wu, Reen
- Abstract
Global protein interaction network (interactome) analysis provides an effective way to understand the relationships between genes. Through this approach, it was demonstrated that the essential genes in yeast tend to be highly connected as well as connected to other highly connected genes. This is in contrast to the genes that are not essential, which share neither of these properties. Using a similar interactome-transcriptome approach, the topological features in the interactome of differentially expressed genes in lung squamous cancer tissues are assessed.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 23, p4205
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti688