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- Title
Prediction of the coupling specificity of GPCRs to four families of G-proteins using hidden Markov models and artificial neural networks.
- Authors
Sgourakis, Nikolaos G; Bagos, Pantelis G; Hamodrakas, Stavros J
- Abstract
G-protein coupled receptors are a major class of eukaryotic cell-surface receptors. A very important aspect of their function is the specific interaction (coupling) with members of four G-protein families. A single GPCR may interact with members of more than one G-protein families (promiscuous coupling). To date all published methods that predict the coupling specificity of GPCRs are restricted to three main coupling groups G(i/o), G(q/11) and G(s), not including G(12/13)-coupled or other promiscuous receptors.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 22, p4101
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti679