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- Title
Prediction of glycan structures from gene expression data based on glycosyltransferase reactions.
- Authors
Kawano, Shin; Hashimoto, Kosuke; Miyama, Takashi; Goto, Susumu; Kanehisa, Minoru
- Abstract
Glycan chains are synthesized by a combination of several kinds of glycosyltransferases (GTs). Thus, once we know the repertoire of GTs in the genome, in the transcriptome or in the proteome, it should in principle be possible to predict the repertoire of possible glycan structures in an organism or at a specific stage of the cell. Here, we show that a repertoire of glycan structures can be predicted from the set of GTs in the transcriptome. That is, using knowledge about glycan structure characteristics, we can predict glycan structures from incomplete or noisy data such as DNA microarray data.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 21, p3976
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti666