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- Title
Non-transcriptional pathway features reconstructed from secondary effects of RNA interference.
- Authors
Markowetz, Florian; Bloch, Jacques; Spang, Rainer
- Abstract
Cellular signaling pathways, which are not modulated on a transcriptional level, cannot be directly deduced from expression profiling experiments. The situation changes, when external interventions such as RNA interference or gene knock-outs come into play. Even if the expression of the signaling genes is not changed, secondary effects in downstream genes shed light on the pathway, and allow partial reconstruction of its topology.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 21, p4026
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti662