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- Title
Bias in the estimation of false discovery rate in microarray studies.
- Authors
Pawitan, Yudi; Murthy, Karuturi R Krishna; Michiels, Stefan; Ploner, Alexander
- Abstract
The false discovery rate (FDR) provides a key statistical assessment for microarray studies. Its value depends on the proportion pi(0) of non-differentially expressed (non-DE) genes. In most microarray studies, many genes have small effects not easily separable from non-DE genes. As a result, current methods often overestimate pi(0) and FDR, leading to unnecessary loss of power in the overall analysis.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 20, p3865
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti626