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- Title
A latent variable model for chemogenomic profiling.
- Authors
Flaherty, Patrick; Giaever, Guri; Kumm, Jochen; Jordan, Michael I; Arkin, Adam P
- Abstract
In haploinsufficiency profiling data, pleiotropic genes are often misclassified by clustering algorithms that impose the constraint that a gene or experiment belong to only one cluster. We have developed a general probabilistic model that clusters genes and experiments without requiring that a given gene or drug only appear in one cluster. The model also incorporates the functional annotation of known genes to guide the clustering procedure.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 15, p3286
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti515