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- Title
Inferring protein-protein interactions through high-throughput interaction data from diverse organisms.
- Authors
Liu, Yin; Liu, Nianjun; Zhao, Hongyu
- Abstract
Identifying protein-protein interactions is critical for understanding cellular processes. Because protein domains represent binding modules and are responsible for the interactions between proteins, computational approaches have been proposed to predict protein interactions at the domain level. The fact that protein domains are likely evolutionarily conserved allows us to pool information from data across multiple organisms for the inference of domain-domain and protein-protein interaction probabilities.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 15, p3279
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti492