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- Title
Quasi-consensus-based comparison of profile hidden Markov models for protein sequences.
- Authors
Kahsay, Robel Y; Wang, Guoli; Gao, Guang; Liao, Li; Dunbrack, Roland
- Abstract
A simple approach for the sensitive detection of distant relationships among protein families and for sequence-structure alignment via comparison of hidden Markov models based on their quasi-consensus sequences is presented. Using a previously published benchmark dataset, the approach is demonstrated to give better homology detection and yield alignments with improved accuracy in comparison to an existing state-of-the-art dynamic programming profile-profile comparison method. This method also runs significantly faster and is therefore suitable for a server covering the rapidly increasing structure database. A server based on this method is available at http://liao.cis.udel.edu/website/servers/modmod
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 10, p2287
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti374