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- Title
Prediction of the phenotypic effects of non-synonymous single nucleotide polymorphisms using structural and evolutionary information.
- Authors
Bao, Lei; Cui, Yan
- Abstract
There has been great expectation that the knowledge of an individual's genotype will provide a basis for assessing susceptibility to diseases and designing individualized therapy. Non-synonymous single nucleotide polymorphisms (nsSNPs) that lead to an amino acid change in the protein product are of particular interest because they account for nearly half of the known genetic variations related to human inherited diseases. To facilitate the identification of disease-associated nsSNPs from a large number of neutral nsSNPs, it is important to develop computational tools to predict the phenotypic effects of nsSNPs.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 10, p2185
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti365