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- Title
Identification of GPI anchor attachment signals by a Kohonen self-organizing map.
- Authors
Fankhauser, Niklaus; Mäser, Pascal
- Abstract
Anchoring of proteins to the extracytosolic leaflet of membranes via C-terminal attachment of glycosylphosphatidylinositol (GPI) is ubiquitous and essential in eukaryotes. The signal for GPI-anchoring is confined to the C-terminus of the target protein. In order to identify anchoring signals in silico, we have trained neural networks on known GPI-anchored proteins, systematically optimizing input parameters.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 9, p1846
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti299