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- Title
Mtreemix: a software package for learning and using mixture models of mutagenetic trees.
- Authors
Beerenwinkel, Niko; Rahnenführer, Jörg; Kaiser, Rolf; Hoffmann, Daniel; Selbig, Joachim; Lengauer, Thomas
- Abstract
Mixture models of mutagenetic trees constitute a class of probabilistic models for describing evolutionary processes that are characterized by the accumulation of permanent genetic changes. They have been applied to model the accumulation of chromosomal gains and losses in tumor development and the development of drug resistance-associated mutations in the HIV genome.Mtreemix is a software package for estimating mutagenetic trees mixture models from observed cross-sectional data and for using these models for predictions. We provide programs for model fitting, model selection, simulation, likelihood computation and waiting time estimation.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 9, p2106
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti274