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- Title
Transcription factor binding site identification using the self-organizing map.
- Authors
Mahony, Shaun; Hendrix, David; Golden, Aaron; Smith, Terry J; Rokhsar, Daniel S
- Abstract
The automatic identification of over-represented motifs present in a collection of sequences continues to be a challenging problem in computational biology. In this paper, we propose a self-organizing map of position weight matrices as an alternative method for motif discovery. The advantage of this approach is that it can be used to simultaneously characterize every feature present in the dataset, thus lessening the chance that weaker signals will be missed. Features identified are ranked in terms of over-representation relative to a background model.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 9, p1807
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti256