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- Title
Genome-wide decoding of hierarchical modular structure of transcriptional regulation by cis-element and expression clustering.
- Authors
Leyfer, Dmitriy; Weng, Zhiping
- Abstract
A holistic approach to the study of cellular processes is identifying both gene-expression changes and regulatory elements promoting such changes. Cellular regulatory processes can be viewed as transcriptional modules (TMs), groups of coexpressed genes regulated by groups of transcription factors (TFs). We set out to devise a method that would identify TMs while avoiding arbitrary thresholds on TM sizes and number.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21 Suppl 2, pii197
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti1131