We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Whole-proteome prediction of protein function via graph-theoretic analysis of interaction maps.
- Authors
Nabieva, Elena; Jim, Kam; Agarwal, Amit; Chazelle, Bernard; Singh, Mona
- Abstract
Determining protein function is one of the most important problems in the post-genomic era. For the typical proteome, there are no functional annotations for one-third or more of its proteins. Recent high-throughput experiments have determined proteome-scale protein physical interaction maps for several organisms. These physical interactions are complemented by an abundance of data about other types of functional relationships between proteins, including genetic interactions, knowledge about co-expression and shared evolutionary history. Taken together, these pairwise linkages can be used to build whole-proteome protein interaction maps.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21 Suppl 1, pi302
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti1054