We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A simple procedure for estimating the false discovery rate.
- Authors
Dalmasso, Cyril; Broët, Philippe; Moreau, Thierry
- Abstract
The most used criterion in microarray data analysis is nowadays the false discovery rate (FDR). In the framework of estimating procedures based on the marginal distribution of the P-values without any assumption on gene expression changes, estimators of the FDR are necessarily conservatively biased. Indeed, only an upper bound estimate can be obtained for the key quantity pi0, which is the probability for a gene to be unmodified. In this paper, we propose a novel family of estimators for pi0 that allows the calculation of FDR.
- Publication
Bioinformatics (Oxford, England), 2005, Vol 21, Issue 5, p660
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bti063