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- Title
IMGT/JunctionAnalysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs.
- Authors
Yousfi Monod, Mehdi; Giudicelli, Véronique; Chaume, Denys; Lefranc, Marie-Paule
- Abstract
To create the enormous diversity of 10(12) immunoglobulins (IG) and T cell receptors (TR) per individual, very complex mechanisms occur at the DNA level: the combinatorial diversity results from the junction of the variable (V), diversity (D) and joining (J) genes; the N-diversity represents the addition at random of nucleotides not encoded in the genome; and somatic hypermutations occur in IG rearranged sequences. The accurate annotation of the junction between V, D, J genes in rearranged IG and TR sequences represents therefore a huge challenge by its uniqueness and complexity. We developed IMGT/JunctionAnalysis to analyse automatically in detail the IG and TR junctions, according to the IMGT Scientific chart rules, based on the IMGT-ONTOLOGY concepts.
- Publication
Bioinformatics (Oxford, England), 2004, Vol 20 Suppl 1, pi379
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bth945