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- Title
Improved techniques for the identification of pseudogenes.
- Authors
Coin, L; Durbin, R
- Abstract
Pseudogenes are the remnants of genomic sequences of genes which are no longer functional. They are frequent in most eukaryotic genomes, and an important resource for comparative genomics. However, pseudogenes are often mis-annotated as functional genes in sequence databases. Current methods for identifying pseudogenes include methods which rely on the presence of stop codons and frameshifts, as well as methods based on the ratio of non-silent to silent nucleotide substitution rates (dN/dS). A recent survey concluded that 50% of human pseudogenes have no detectable truncation in their pseudo-coding regions, indicating that the former methods lack sensitivity. The latter methods have been used to find sets of genes enriched for pseudogenes, but are not specific enough to accurately separate pseudogenes from expressed genes.
- Publication
Bioinformatics (Oxford, England), 2004, Vol 20 Suppl 1, pi94
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bth942