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- Title
Transmembrane proteins in the Protein Data Bank: identification and classification.
- Authors
Tusnády, Gábor E; Dosztányi, Zsuzsanna; Simon, István
- Abstract
Integral membrane proteins play important roles in living cells. Although these proteins are estimated to constitute 25% of proteins at a genomic scale, the Protein Data Bank (PDB) contains only a few hundred membrane proteins due to the difficulties with experimental techniques. The presence of transmembrane proteins in the structure data bank, however, is quite invisible, as the annotation of these entries is rather poor. Even if a protein is identified as a transmembrane one, the possible location of the lipid bilayer is not indicated in the PDB because these proteins are crystallized without their natural lipid bilayer, and currently no method is publicly available to detect the possible membrane plane using the atomic coordinates of membrane proteins.
- Publication
Bioinformatics (Oxford, England), 2004, Vol 20, Issue 17, p2964
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bth340