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- Title
Prediction of similarly acting cis-regulatory modules by subsequence profiling and comparative genomics in Drosophila melanogaster and D.pseudoobscura.
- Authors
Grad, Yonatan H; Roth, Frederick P; Halfon, Marc S; Church, George M
- Abstract
To date, computational searches for cis-regulatory modules (CRMs) have relied on two methods. The first, phylogenetic footprinting, has been used to find CRMs in non-coding sequence, but does not directly link DNA sequence with spatio-temporal patterns of expression. The second, based on searches for combinations of transcription factor (TF) binding motifs, has been employed in genome-wide discovery of similarly acting enhancers, but requires prior knowledge of the set of TFs acting at the CRM and the TFs' binding motifs.
- Publication
Bioinformatics (Oxford, England), 2004, Vol 20, Issue 16, p2738
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bth320