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- Title
Alignment of RNA base pairing probability matrices.
- Authors
Hofacker, Ivo L; Bernhart, Stephan H F; Stadler, Peter F
- Abstract
Many classes of functional RNA molecules are characterized by highly conserved secondary structures but little detectable sequence similarity. Reliable multiple alignments can therefore be constructed only when the shared structural features are taken into account. Since multiple alignments are used as input for many subsequent methods of data analysis, structure-based alignments are an indispensable necessity in RNA bioinformatics.
- Publication
Bioinformatics (Oxford, England), 2004, Vol 20, Issue 14, p2222
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bth229