We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Enhanced homology searching through genome reading frame predetermination.
- Authors
Yuan, Jeffrey; Bush, Bruce; Elbrecht, Alex; Liu, Yuan; Zhang, Theresa; Zhao, Wenqing; Blevins, Richard
- Abstract
Many bioinformatic approaches exist for finding novel genes within genomic sequence data. Traditionally, homology search-based methods are often the first approach employed in determining whether a novel gene exists that is similar to a known gene. Unfortunately, distantly related genes or motifs often are difficult to find using single query-based homology search algorithms against large sequence datasets such as the human genome. Therefore, the motivation behind this work was to develop an approach to enhance the sensitivity of traditional single query-based homology algorithms against genomic data without losing search selectivity.
- Publication
Bioinformatics (Oxford, England), 2004, Vol 20, Issue 9, p1416
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bth115