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- Title
Gene structure prediction from consensus spliced alignment of multiple ESTs matching the same genomic locus.
- Authors
Brendel, Volker; Xing, Liqun; Zhu, Wei
- Abstract
Accurate gene structure annotation is a challenging computational problem in genomics. The best results are achieved with spliced alignment of full-length cDNAs or multiple expressed sequence tags (ESTs) with sufficient overlap to cover the entire gene. For most species, cDNA and EST collections are far from comprehensive. We sought to overcome this bottleneck by exploring the possibility of using combined EST resources from fairly diverged species that still share a common gene space. Previous spliced alignment tools were found inadequate for this task because they rely on very high sequence similarity between the ESTs and the genomic DNA.
- Publication
Bioinformatics (Oxford, England), 2004, Vol 20, Issue 7, p1157
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bth058