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- Title
Phylogenomic inference of protein molecular function: advances and challenges.
- Authors
Sjölander, Kimmen
- Abstract
Protein families evolve a multiplicity of functions through gene duplication, speciation and other processes. As a number of studies have shown, standard methods of protein function prediction produce systematic errors on these data. Phylogenomic analysis--combining phylogenetic tree construction, integration of experimental data and differentiation of orthologs and paralogs--has been proposed to address these errors and improve the accuracy of functional classification. The explicit integration of structure prediction and analysis in this framework, which we call structural phylogenomics, provides additional insights into protein superfamily evolution.
- Publication
Bioinformatics (Oxford, England), 2004, Vol 20, Issue 2, p170
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bth021