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- Title
Disulfide connectivity prediction using recursive neural networks and evolutionary information.
- Authors
Vullo, Alessandro; Frasconi, Paolo
- Abstract
We focus on the prediction of disulfide bridges in proteins starting from their amino acid sequence and from the knowledge of the disulfide bonding state of each cysteine. The location of disulfide bridges is a structural feature that conveys important information about the protein main chain conformation and can therefore help towards the solution of the folding problem. Existing approaches based on weighted graph matching algorithms do not take advantage of evolutionary information. Recursive neural networks (RNN), on the other hand, can handle in a natural way complex data structures such as graphs whose vertices are labeled by real vectors, allowing us to incorporate multiple alignment profiles in the graphical representation of disulfide connectivity patterns.
- Publication
Bioinformatics (Oxford, England), 2004, Vol 20, Issue 5, p653
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btg463