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- Title
Prediction of regulatory networks: genome-wide identification of transcription factor targets from gene expression data.
- Authors
Qian, Jiang; Lin, Jimmy; Luscombe, Nicholas M; Yu, Haiyuan; Gerstein, Mark
- Abstract
Defining regulatory networks, linking transcription factors (TFs) to their targets, is a central problem in post-genomic biology. One might imagine one could readily determine these networks through inspection of gene expression data. However, the relationship between the expression timecourse of a transcription factor and its target is not obvious (e.g. simple correlation over the timecourse), and current analysis methods, such as hierarchical clustering, have not been very successful in deciphering them.
- Publication
Bioinformatics (Oxford, England), 2003, Vol 19, Issue 15, p1917
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btg347