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- Title
Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays.
- Authors
Jain, Nitin; Thatte, Jayant; Braciale, Thomas; Ley, Klaus; O'Connell, Michael; Lee, Jae K
- Abstract
In microarray studies gene discovery based on fold-change values is often misleading because error variability for each gene is heterogeneous under different biological conditions and intensity ranges. Several statistical testing methods for differential gene expression have been suggested, but some of these approaches are underpowered and result in high false positive rates because within-gene variance estimates are based on a small number of replicated arrays.
- Publication
Bioinformatics (Oxford, England), 2003, Vol 19, Issue 15, p1945
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btg264