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- Title
Investigating semantic similarity measures across the Gene Ontology: the relationship between sequence and annotation.
- Authors
Lord, P W; Stevens, R D; Brass, A; Goble, C A
- Abstract
Many bioinformatics data resources not only hold data in the form of sequences, but also as annotation. In the majority of cases, annotation is written as scientific natural language: this is suitable for humans, but not particularly useful for machine processing. Ontologies offer a mechanism by which knowledge can be represented in a form capable of such processing. In this paper we investigate the use of ontological annotation to measure the similarities in knowledge content or 'semantic similarity' between entries in a data resource. These allow a bioinformatician to perform a similarity measure over annotation in an analogous manner to those performed over sequences. A measure of semantic similarity for the knowledge component of bioinformatics resources should afford a biologist a new tool in their repertoire of analyses.
- Publication
Bioinformatics (Oxford, England), 2003, Vol 19, Issue 10, p1275
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btg153