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- Title
Extracting active pathways from gene expression data.
- Authors
Vert, Jean Philippe; Kanehisa, Minoru
- Abstract
A promising way to make sense out of gene expression profiles is to relate them to the activity of metabolic and signalling pathways. Each pathway usually involves many genes, such as enzymes, which can themselves participate in many pathways. The set of all known pathways can therefore be represented by a complex network of genes. Searching for regularities in the set of gene expression profiles with respect to the topology of this gene network is a way to automatically extract active pathways and their associated patterns of activity.
- Publication
Bioinformatics (Oxford, England), 2003, Vol 19 Suppl 2, pii238
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btg1084