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- Title
Searching for statistically significant regulatory modules.
- Authors
Bailey, Timothy L; Noble, William Stafford
- Abstract
The regulatory machinery controlling gene expression is complex, frequently requiring multiple, simultaneous DNA-protein interactions. The rate at which a gene is transcribed may depend upon the presence or absence of a collection of transcription factors bound to the DNA near the gene. Locating transcription factor binding sites in genomic DNA is difficult because the individual sites are small and tend to occur frequently by chance. True binding sites may be identified by their tendency to occur in clusters, sometimes known as regulatory modules.
- Publication
Bioinformatics (Oxford, England), 2003, Vol 19 Suppl 2, pii16
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btg1054