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Title
Computational detection of cis -regulatory modules.
Authors
Aerts, Stein; Van Loo, Peter; Thijs, Gert; Moreau, Yves; De Moor, Bart
Abstract
The transcriptional regulation of a metazoan gene depends on the cooperative action of multiple transcription factors that bind to cis-regulatory modules (CRMs) located in the neighborhood of the gene. By integrating multiple signals, CRMs confer an organism specific spatial and temporal rate of transcription.