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- Title
Gene structure-based splice variant deconvolution using a microarray platform.
- Authors
Wang, Hui; Hubbell, Earl; Hu, Jing-shan; Mei, Gangwu; Cline, Melissa; Lu, Gang; Clark, Tyson; Siani-Rose, Michael A; Ares, Manuel; Kulp, David C; Haussler, David
- Abstract
Alternative splicing allows a single gene to generate multiple mRNAs, which can be translated into functionally and structurally diverse proteins. One gene can have multiple variants coexisting at different concentrations. Estimating the relative abundance of each variant is important for the study of underlying biological function. Microarrays are standard tools that measure gene expression. But most design and analysis has not accounted for splice variants. Thus splice variant-specific chip designs and analysis algorithms are needed for accurate gene expression profiling.
- Publication
Bioinformatics (Oxford, England), 2003, Vol 19 Suppl 1, pi315
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btg1044