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- Title
Predicting bacterial transcription units using sequence and expression data.
- Authors
Bockhorst, Joseph; Qiu, Yu; Glasner, Jeremy; Liu, Mingzhu; Blattner, Frederick; Craven, Mark
- Abstract
A key aspect of elucidating gene regulation in bacterial genomes is identifying the basic units of transcription. We present a method, based on probabilistic language models, that we apply to predict operons, promoters and terminators in the genome of Escherichia coli K-12. Our approach has two key properties: (i) it provides a coherent set of predictions for related regulatory elements of various types and (ii) it takes advantage of both DNA sequence and gene expression data, including expression measurements from inter-genic probes.
- Publication
Bioinformatics (Oxford, England), 2003, Vol 19 Suppl 1, pi34
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btg1003