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- Title
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.
- Authors
Bolstad, B M; Irizarry, R A; Astrand, M; Speed, T P
- Abstract
When running experiments that involve multiple high density oligonucleotide arrays, it is important to remove sources of variation between arrays of non-biological origin. Normalization is a process for reducing this variation. It is common to see non-linear relations between arrays and the standard normalization provided by Affymetrix does not perform well in these situations.
- Publication
Bioinformatics (Oxford, England), 2003, Vol 19, Issue 2, p185
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/19.2.185