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Title
Analysis of whole-genome microarray replicates using mixed models.
Authors
Wernisch, Lorenz; Kendall, Sharon L; Soneji, Shamit; Wietzorrek, Andreas; Parish, Tanya; Hinds, Jason; Butcher, Philip D; Stoker, Neil G
Abstract
Microarray experiments are inherently noisy. Replication is the key to estimating realistic fold-changes despite such noise. In the analysis of the various sources of noise the dependency structure of the replication needs to be taken into account.