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- Title
ConSurf: identification of functional regions in proteins by surface-mapping of phylogenetic information.
- Authors
Glaser, Fabian; Pupko, Tal; Paz, Inbal; Bell, Rachel E; Bechor-Shental, Dalit; Martz, Eric; Ben-Tal, Nir
- Abstract
We recently developed algorithmic tools for the identification of functionally important regions in proteins of known three dimensional structure by estimating the degree of conservation of the amino-acid sites among their close sequence homologues. Projecting the conservation grades onto the molecular surface of these proteins reveals patches of highly conserved (or occasionally highly variable) residues that are often of important biological function. We present a new web server, ConSurf, which automates these algorithmic tools. ConSurf may be used for high-throughput characterization of functional regions in proteins.
- Publication
Bioinformatics (Oxford, England), 2003, Vol 19, Issue 1, p163
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/19.1.163