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- Title
Stochastic pairwise alignments.
- Authors
Mückstein, U; Hofacker, I L; Stadler, P F
- Abstract
The level of sequence conservation between related nucleic acids or proteins often varies considerably along the sequence. Both regions with high variability (mutational hot-spots) and regions of almost perfect sequence identity may occur in the same pair of molecules. The reliability of an alignment therefore strongly depends on the level of local sequence similarity. Especially in regions of high variability, many alignments of almost equal quality exist, and the optimal alignment is highly arbitrary.
- Publication
Bioinformatics (Oxford, England), 2002, Vol 18 Suppl 2, pS153
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/18.suppl_2.s153