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- Title
A variance-stabilizing transformation for gene-expression microarray data.
- Authors
Durbin, B P; Hardin, J S; Hawkins, D M; Rocke, D M
- Abstract
Standard statistical techniques often assume that data are normally distributed, with constant variance not depending on the mean of the data. Data that violate these assumptions can often be brought in line with the assumptions by application of a transformation. Gene-expression microarray data have a complicated error structure, with a variance that changes with the mean in a non-linear fashion. Log transformations, which are often applied to microarray data, can inflate the variance of observations near background.
- Publication
Bioinformatics (Oxford, England), 2002, Vol 18 Suppl 1, pS105
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/18.suppl_1.s105