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- Title
Analysis of mRNA expression and protein abundance data: an approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts.
- Authors
Greenbaum, Dov; Jansen, Ronald; Gerstein, Mark
- Abstract
Protein abundance is related to mRNA expression through many different cellular processes. Up to now, there have been conflicting results on how correlated the levels of these two quantities are. Given that expression and abundance data are significantly more complex and noisy than the underlying genomic sequence information, it is reasonable to simplify and average them in terms of broad proteomic categories and features (e.g. functions or secondary structures), for understanding their relationship. Furthermore, it will be essential to integrate, within a common framework, the results of many varied experiments by different investigators. This will allow one to survey the characteristics of highly expressed genes and proteins.
- Publication
Bioinformatics (Oxford, England), 2002, Vol 18, Issue 4, p585
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/18.4.585