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- Title
Extensive feature detection of N-terminal protein sorting signals.
- Authors
Bannai, Hideo; Tamada, Yoshinori; Maruyama, Osamu; Nakai, Kenta; Miyano, Satoru
- Abstract
The prediction of localization sites of various proteins is an important and challenging problem in the field of molecular biology. TargetP, by Emanuelsson et al. (J. Mol. Biol., 300, 1005-1016, 2000) is a neural network based system which is currently the best predictor in the literature for N-terminal sorting signals. One drawback of neural networks, however, is that it is generally difficult to understand and interpret how and why they make such predictions. In this paper, we aim to generate simple and interpretable rules as predictors, and still achieve a practical prediction accuracy. We adopt an approach which consists of an extensive search for simple rules and various attributes which is partially guided by human intuition.
- Publication
Bioinformatics (Oxford, England), 2002, Vol 18, Issue 2, p298
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/18.2.298