We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Linear modes of gene expression determined by independent component analysis.
- Authors
Liebermeister, Wolfram
- Abstract
The expression of genes is controlled by specific combinations of cellular variables. We applied Independent Component Analysis (ICA) to gene expression data, deriving a linear model based on hidden variables, which we term 'expression modes'. The expression of each gene is a linear function of the expression modes, where, according to the ICA model, the linear influences of different modes show a minimal statistical dependence, and their distributions deviate sharply from the normal distribution.
- Publication
Bioinformatics (Oxford, England), 2002, Vol 18, Issue 1, p51
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/18.1.51