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Title
Analysis of temporal gene expression profiles: clustering by simulated annealing and determining the optimal number of clusters.
Authors
Lukashin, A V; Fuchs, R
Abstract
Cluster analysis of genome-wide expression data from DNA microarray hybridization studies has proved to be a useful tool for identifying biologically relevant groupings of genes and samples. In the present paper, we focus on several important issues related to clustering algorithms that have not yet been fully studied.