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- Title
A higher-order background model improves the detection of promoter regulatory elements by Gibbs sampling.
- Authors
Thijs, G; Lescot, M; Marchal, K; Rombauts, S; De Moor, B; Rouzé, P; Moreau, Y
- Abstract
Transcriptome analysis allows detection and clustering of genes that are coexpressed under various biological circumstances. Under the assumption that coregulated genes share cis-acting regulatory elements, it is important to investigate the upstream sequences controlling the transcription of these genes. To improve the robustness of the Gibbs sampling algorithm to noisy data sets we propose an extension of this algorithm for motif finding with a higher-order background model.
- Publication
Bioinformatics (Oxford, England), 2001, Vol 17, Issue 12, p1113
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/17.12.1113