We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Enrichment of regulatory signals in conserved non-coding genomic sequence.
- Authors
Levy, S; Hannenhalli, S; Workman, C
- Abstract
Whole genome shotgun sequencing strategies generate sequence data prior to the application of assembly methodologies that result in contiguous sequence. Sequence reads can be employed to indicate regions of conservation between closely related species for which only one genome has been assembled. Consequently, by using pairwise sequence alignments methods it is possible to identify novel, non-repetitive, conserved segments in non-coding sequence that exist between the assembled human genome and mouse whole genome shotgun sequencing fragments. Conserved non-coding regions identify potentially functional DNA that could be involved in transcriptional regulation.
- Publication
Bioinformatics (Oxford, England), 2001, Vol 17, Issue 10, p871
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/17.10.871