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- Title
Sequence analysis by additive scales: DNA structure for sequences and repeats of all lengths.
- Authors
Baldi, P; Baisnée, P F
- Abstract
DNA structure plays an important role in a variety of biological processes. Different di- and tri-nucleotide scales have been proposed to capture various aspects of DNA structure including base stacking energy, propeller twist angle, protein deformability, bendability, and position preference. Yet, a general framework for the computational analysis and prediction of DNA structure is still lacking. Such a framework should in particular address the following issues: (1) construction of sequences with extremal properties; (2) quantitative evaluation of sequences with respect to a given genomic background; (3) automatic extraction of extremal sequences and profiles from genomic databases; (4) distribution and asymptotic behavior as the length N of the sequences increases; and (5) complete analysis of correlations between scales.
- Publication
Bioinformatics (Oxford, England), 2000, Vol 16, Issue 10, p865
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/16.10.865