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- Title
A historical perspective on gene/protein functional assignment.
- Authors
Hodgman, T C
- Abstract
Sequence determination and analysis began on proteins in the 1950s, with RNA starting about a decade later and DNA a similar period later still. Hence many of the concepts for function prediction were first developed by looking at amino acid sequences. Over time these methods have become much more sophisticated, allowing better discrimination of only weak similarities. The most recent developments concern an examination of contextual information, such as operon structure, metabolic reconstruction or co-expression profiles.
- Publication
Bioinformatics (Oxford, England), 2000, Vol 16, Issue 1, p10
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/16.1.10