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- Title
Identifying DNA and protein patterns with statistically significant alignments of multiple sequences.
- Authors
Hertz, G Z; Stormo, G D
- Abstract
Molecular biologists frequently can obtain interesting insight by aligning a set of related DNA, RNA or protein sequences. Such alignments can be used to determine either evolutionary or functional relationships. Our interest is in identifying functional relationships. Unless the sequences are very similar, it is necessary to have a specific strategy for measuring-or scoring-the relatedness of the aligned sequences. If the alignment is not known, one can be determined by finding an alignment that optimizes the scoring scheme.
- Publication
Bioinformatics (Oxford, England), 1999, Vol 15, Issue 7-8, p563
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/15.7.563